Macrophages of spermidine treated mice could adoptively transfer the protective effect on EAEThe above results showed that spermidine inhibited pro inflammatory activity of macrophages. Given the plasticity of macrophage mediated immunoregulation, we questioned whether the immunophenotype of macrophages could be affected by spermidine. To investigate whether spermidine treated macrophages possess the anti inflammatory function, we isolated splenic macrophages from spermidine treated EAE mice and vehicle control mice on day 15 post immunization, and then transferred into recipient EAE mice on the day of disease onset. wholesale jerseys
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Horrillo suffered broken bones and head trauma but should make a full recovery.But the technically challenging descent caught out Horrillo, who crashed and was found around 60m below his bike as paramedics recovered him from deep in a ravine.He had to be winched into a helicoptor, which took him to a Bergamo hospital.The Rabobank team doctor said Horrillo had sustained fractures to his thigh bones, kneecap and neck, as well as suffering a perforated lung and concussion. He was due to undergo an operation on his leg and knee on Sunday, but scans showed no sign of brain damage.The leaders were allowed to stay out until 16km from the finish when the peloton swallowed them up.But moments later, Siutsou, from Belarus, flew away from the pack and quickly built a 38 second lead.The Team Columbia rider appeared to be fading as he rode through the cobbled streets of Bergamo, but he found one last burst of energy to finish 21 seconds ahead of the field.”I live just 25km from Bergamo, parts of the course pass by there,” said Siutsou.”I know the roads by heart and I know when the best moment is to attack.”This is my finest win and at the finish line, my wife, who is expecting a baby, was waiting.”Sunday’s ninth stage is a 10 lap 165km race around Milan.Britain’s Mark Cavendish is among those tipped for the stage win.Looking forward to that possibility, Columbia team boss Bob Stapleton said: “We hope that Mark can come out to play, and show again that he’s the fastest sprinter in the world.”The course suits him for sure and we’ll try to win another stage and keep the run of success going.”Stage Eight result:1. Kanstantsin Siutsou (Blr/Columbia ) 5hrs 04mins 34secs 2.